期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 66, 期 1, 页码 24-28出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2009.08.015
关键词
Clostridium; Difficile; tcdC
资金
- National Center for Research Resources, National Institutes of Health (NIH) [1 UL1 RR024150-0]
- Mayo Foundation
- NATIONAL CENTER FOR RESEARCH RESOURCES [UL1RR024150] Funding Source: NIH RePORTER
We assessed the prevalence of tcdC deletion-carrying Clostridium difficile using a stool polymerase chain reaction (PCR) assay that detects previously described 18- and 39-bp deletions (J. Clin. Microbiol. 2008;46:1996). We divided inpatients into 2 groups, those for whom the assay detected a deletion in tcdC and those for whom no deletion was detected. We compared risk factors (antibiotic use, hospitalization, nursing home stay, immunocompromise, age >65 years), complications (pseudomembranous colitis, toxic megacolon, colonic perforation, colectomy, and intensive care unit admission), duration of antibiotic treatment, and 30-day mortality between the groups. Forty-two of 141 patients had deletion-positive C. difficile. Prior nursing home stay and age >65 years were significantly more common in the deletion-positive group. Other risk factors, complications, antibiotic duration, and mortality did not differ significantly. Deletion-carrying C. difficile was commonly present but not associated with more severe disease and not markedly different in terms of risk factor profile. Severity of disease was relatively low, regardless of the presence or absence of a deletion. (C) 2010 Elsevier Inc. All rights reserved.
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