期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 61, 期 4, 页码 381-386出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2008.03.018
关键词
Tubex (TM); Typhidot (R); typhoid fever; Salmonella typhi; Bangladesh
Tubex (TM) and Typhidot (R), rapid tests for typhoid fever, performed well in evaluations conducted in hospital settings among patients with culture-confinned typhoid fever. We evaluated these tests in a community clinic in Bangladesh. Blood samples were obtained from 867 febrile patients for culture, Typhidot (R) and Tubex (TM) tests. Considering the 43 blood culture-confirmed cases of typhoid fever as typhoid positive and the 24 other confirmed bacteremia cases as typhoid negative, Tubex (TM) was 60% sensitive and 58% specific, with 90% positive and 58% negative predictive values (NPVs); Typhidot (R) was 67% sensitive and 54% specific, with 85% positive and 81% NPVs. When blood culture-negative patients and other bacteremia cases together were considered typhoid negative, positive predictive values were only 14% for Tubex (TM) and 13% for Typhidot (R), increasing to only 38% and 20% when restricted to patients with >= 7 days of fever. We conclude that the value of Tubex (TM) and Typhidot (R) tests for typhoid fever diagnosis in a community clinic in urban Bangladesh is low. (c) 2008 Elsevier Inc. All rights reserved.
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