期刊
DIABETOLOGIA
卷 61, 期 12, 页码 2570-2579出版社
SPRINGER
DOI: 10.1007/s00125-018-4720-1
关键词
Ceramides; Liver fat; Obesity; Prediabetes; Type 2 diabetes mellitus; Visceral adiposity
资金
- National Institute of Diabetes and Digestive and Kidney Diseases of the National Institute of Health [K23 DK106520]
- Dedman Family Scholarship in Clinical Care from UT Southwestern
- National Center for Advancing Translational Sciences of the National Institutes of Health [UL1TR001105]
- Donald W. Reynolds Foundation
- Merck & Co., Inc., Kenilworth, NJ, USA
Aims/hypothesisCeramides are sphingolipids that contribute to insulin resistance in preclinical studies. We hypothesised that plasma ceramides would be associated with body fat distribution, insulin resistance and incident type 2 diabetes in a multi-ethnic cohort.MethodsA total of 1557 participants in the Dallas Heart Study without type 2 diabetes underwent measurements of metabolic biomarkers, fat depots by MRI and plasma ceramides by liquid chromatography-mass spectrometry. Diabetes outcomes were assessed after 7years. Associations of body fat and insulin resistance with ceramides at baseline and of ceramides with incident diabetes outcomes were analysed.ResultsThe cohort had a mean age of 43years, with 58% women, 45% black participants and a mean BMI of 28kg/m(2). Total cholesterol levels were associated with all ceramides, but higher triacylglycerols and lower HDL-cholesterol and adiponectin were associated only with saturated fatty acid chain ceramides (p<0.0003). After adjusting for clinical characteristics and total body fat, visceral adipose tissue was positively associated with saturated fatty acid ceramides (per SD, =0.16 to 0.18) and inversely associated with polyunsaturated fatty acid ceramides (=-0.14 to -0.16, p<0.001 for all). Lower-body subcutaneous fat showed an opposite pattern to that for visceral fat. HOMA-IR was positively associated with saturated (=0.08 to 0.09, p<0.001) and inversely with polyunsaturated ceramides (=-0.06 to -0.07, p<0.05). Ceramides were not associated with incident type 2 diabetes after adjustment for clinical factors.Conclusions/interpretationPlasma ceramides demonstrate a biologically complex relationship with metabolic and imaging indicators of dysfunctional adiposity. The role of ceramides in a shared pathway of metabolic dysfunction linking visceral adiposity and insulin resistance requires further investigation.
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