期刊
DIABETOLOGIA
卷 56, 期 1, 页码 47-59出版社
SPRINGER
DOI: 10.1007/s00125-012-2718-7
关键词
Case-cohort study; Diet; Meat; Type 2 diabetes
资金
- European Union (European Community) [LSHM-CT-2006-037197]
- Italian Association for Research on Cancer (AIRC)
- PIO Programma Integrato Oncologia
- Dutch Ministry of Public Health, Welfare and Sports (VWS)
- Netherlands Cancer Registry (NKR)
- LK Research Funds
- Dutch Prevention Funds
- Dutch ZON (Zorg Onderzoek Nederland)
- World Cancer Research Fund (WCRF)
- Statistics Netherlands
- Cancer Research UK
- Swedish Research Council
- Novo Nordisk
- Swedish Diabetes Association
- Swedish Heart-Lung Foundation
- Health Research Fund of the Spanish Ministry of Health
- Murcia Regional Government [6236]
- Medical Research Council UK
- Danish Cancer Society
- Asturias Regional Government
- Vasterboten County Council
- NL Agency [IGE05012]
- board of UMC Utrecht
- German Cancer Aid
- AIRE-ONLUS Ragusa
- AVIS-Ragusa
- Sicilian Regional Government
- Imperial College Biomedical Research Centre
- Spanish Ministry of Health [ISCIII RETICC RD06/0020]
- Spanish Regional Government of Andalusia
- Spanish Regional Government of Asturias
- Spanish Regional Government of Basque Country
- Spanish Regional Government of Murcia [6236]
- Spanish Regional Government of Navarra
- Catalan Institute of Oncology
- MRC [MC_UP_A100_1003, MC_UU_12015/1] Funding Source: UKRI
- Medical Research Council [G1000143, MC_UU_12015/1, G0401527, MC_UP_A100_1003] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10114] Funding Source: researchfish
A diet rich in meat has been reported to contribute to the risk of type 2 diabetes. The present study aims to investigate the association between meat consumption and incident type 2 diabetes in the EPIC-InterAct study, a large prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. During 11.7 years of follow-up, 12,403 incident cases of type 2 diabetes were identified among 340,234 adults from eight European countries. A centre-stratified random subsample of 16,835 individuals was selected in order to perform a case-cohort design. Prentice-weighted Cox regression analyses were used to estimate HR and 95% CI for incident diabetes according to meat consumption. Overall, multivariate analyses showed significant positive associations with incident type 2 diabetes for increasing consumption of total meat (50 g increments: HR 1.08; 95% CI 1.05, 1.12), red meat (HR 1.08; 95% CI 1.03, 1.13) and processed meat (HR 1.12; 95% CI 1.05, 1.19), and a borderline positive association with meat iron intake. Effect modifications by sex and class of BMI were observed. In men, the results of the overall analyses were confirmed. In women, the association with total and red meat persisted, although attenuated, while an association with poultry consumption also emerged (HR 1.20; 95% CI 1.07, 1.34). These associations were not evident among obese participants. This prospective study confirms a positive association between high consumption of total and red meat and incident type 2 diabetes in a large cohort of European adults.
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