期刊
DIABETOLOGIA
卷 54, 期 9, 页码 2272-2282出版社
SPRINGER
DOI: 10.1007/s00125-011-2182-9
关键词
Cohort studies; Diabetes mellitus; Epidemiologic research design; Gene-lifestyle interaction; Genetic epidemiology; Type 2 diabetes
资金
- European Union of the European Community [LSHM-CT-2006-037197]
- Spanish Ministry of Health
- CIBER en Epidemiologia y Salud Publica (CIBERESP), Spain
- Murcia Regional Government [6236]
- J. Spranger: Heisenberg-Professorship [SP716/2-1]
- Clinical Research Group
- Research Group (Molecular Nutrition) of the Bundesministerium fur Bildung und Forschung (BMBF)
- NL Agency [IGE05012]
- Board of the UMC Utrecht
- Dutch Ministry of Public Health, Welfare and Sports (VWS)
- Netherlands Cancer Registry (NKR)
- LK Research Funds
- Dutch Prevention Funds
- Dutch ZON (Zorg Onderzoek Nederland)
- World Cancer Research Fund (WCRF)
- Statistics Netherlands (the Netherlands)
- Cancer Research UK
- Swedish Research Council
- The county of V sterbotten
- Deutsche Krebshilfe
- MRC UK
- MRC (Cambridge Lipidomics Biomarker Research Initiative)
- Danish Cancer Society
- Faculty of Health Science, University of Aarhus, Denmark
- Asturias Regional Government
- AIRE-ONLUS Ragusa, AVIS-Ragusa, Sicilian Regional Government
- Wellcome Trust [083270/Z/07/Z]
- MRC [G0601261]
- Wellcome Trust [083270/Z/07/Z] Funding Source: Wellcome Trust
- MRC [G0601261, MC_U106179473, MC_U106179474, MC_EX_G0800783, MC_UP_A100_1003, MC_UP_A090_1006] Funding Source: UKRI
- Medical Research Council [MC_EX_G0800783, G1000143, MC_UP_A090_1006, G0601261, MC_U106179474, MC_U106179471, MC_UP_A100_1003, G0401527, MC_U106179473] Funding Source: researchfish
Studying gene-lifestyle interaction may help to identify lifestyle factors that modify genetic susceptibility and uncover genetic loci exerting important subgroup effects. Adequately powered studies with prospective, unbiased, standardised assessment of key behavioural factors for gene-lifestyle studies are lacking. This case-cohort study aims to investigate how genetic and potentially modifiable lifestyle and behavioural factors, particularly diet and physical activity, interact in their influence on the risk of developing type 2 diabetes. Incident cases of type 2 diabetes occurring in European Prospective Investigation into Cancer and Nutrition (EPIC) cohorts between 1991 and 2007 from eight of the ten EPIC countries were ascertained and verified. Prentice-weighted Cox regression and random-effects meta-analyses were used to investigate differences in diabetes incidence by age and sex. A total of 12,403 verified incident cases of type 2 diabetes occurred during 3.99 million person-years of follow-up of 340,234 EPIC participants eligible for InterAct. We defined a centre-stratified subcohort of 16,154 individuals for comparative analyses. Individuals with incident diabetes who were randomly selected into the subcohort (n = 778) were included as cases in the analyses. All prevalent diabetes cases were excluded from the study. InterAct cases were followed-up for an average of 6.9 years; 49.7% were men. Mean baseline age and age at diagnosis were 55.6 and 62.5 years, mean BMI and waist circumference values were 29.4 kg/m(2) and 102.7 cm in men, and 30.1 kg/m(2) and 92.8 cm in women, respectively. Risk of type 2 diabetes increased linearly with age, with an overall HR of 1.56 (95% CI 1.48-1.64) for a 10 year age difference, adjusted for sex. A male excess in the risk of incident diabetes was consistently observed across all countries, with a pooled HR of 1.51 (95% CI 1.39-1.64), adjusted for age. InterAct is a large, well-powered, prospective study that will inform our understanding of the interplay between genes and lifestyle factors on the risk of type 2 diabetes development.
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