期刊
DIABETOLOGIA
卷 53, 期 1, 页码 111-114出版社
SPRINGER
DOI: 10.1007/s00125-009-1552-z
关键词
Beta cell mass; Cynomolgus monkey; Streptozotocin; Type 1 diabetes; Type 2 diabetes
资金
- NIDDK NIH HHS [R01 DK077967, DK059579, DK077967] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK059579, R01DK077967] Funding Source: NIH RePORTER
We sought to establish the relationship between fasting plasma glucose concentrations and pancreatic fractional beta cell area in adult cynomolgus monkeys (Macaca fascicularis). Fasting plasma glucose and pancreatic fractional beta cell area were measured in 18 control and 17 streptozotocin-treated adult primates (17.0 +/- 1.2 vs 15.4 +/- 1.2 years old). Fasting plasma glucose was increased (12.0 +/- 2.0 vs 3.4 +/- 0.1 mmol/l, p < 0.01) and fractional beta cell area was decreased (0.62 +/- 0.13% vs 2.49 +/- 0.35%, p < 0.01) in streptozotocin-treated monkeys. The relationship between fasting plasma glucose and pancreatic fractional beta cell area was described by a wide range of beta cell areas in controls. In streptozotocin-treated monkeys there was an inflection of fasting blood glucose at similar to 50% of the mean beta cell area in controls with a steep increase in blood glucose for each further decrement in beta cell area. In adult non-human primates a decrement in fractional beta cell area of similar to 50% or more leads to loss of glycaemic control.
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