期刊
JOURNAL OF PATHOLOGY
卷 238, 期 2, 页码 197-204出版社
WILEY
DOI: 10.1002/path.4651
关键词
pancreatic cancer; organoid; preclinical model; patient-derived tumour xenograft
资金
- Cancer Center Support Grant [5P30CA045508]
- Cold Spring Harbor Laboratory Association
- Precision Medicine Research Associates, LLC (PMRA)
- Pancreatic Cancer United Kingdom (PCUK)
- David Rubinstein Center for Pancreatic Cancer Research at Memorial Sloan Kettering Cancer Center (MSKCC)
- Stand Up To Cancer Phillip A. Sharp Innovation in Collaboration Award [SU2C-AACR-PS09]
- Entertainment Industry Foundation
- Stand Up to Cancer/Koningin Wilhelmina Fonds (KWF)
- STARR Foundation [I7-A718]
- Department of Defense (DOD) [W81XWH-13-PRCRP-IA]
- Louis Morin Charitable Trust
- US National Institutes of Health (NIH) [5P30CA45508-26, 5P50CA101955-07, 1U10CA180944-01, 5U01CA168409-3, 1R01CA190092-01, 1F32CA180717-01A1]
- UAB/UMN SPORE [CA101955]
- KWF [PF-HUBR 2007-3956]
- NATIONAL CANCER INSTITUTE [R01CA190092, P30CA045508, P50CA101955, U10CA180944, U01CA168409, P20CA101955, P30CA008748, F32CA180717] Funding Source: NIH RePORTER
Pancreatic ductal adenocarcinoma (PDA) is one of the most difficult human malignancies to treat. The 5-year survival rate of PDA patients is 7% and PDA is predicted to become the second leading cancer-related cause of death in the USA. Despite intensive efforts, the translation of findings in preclinical studies has been ineffective, due partially to the lack of preclinical models that faithfully recapitulate features of human PDA. Here, we review current preclinical models for human PDA (eg human PDA cell lines, cell line-based xenografts and patient-derived tumour xenografts). In addition, we discuss potential applications of the recently developed pancreatic ductal organoids, three-dimensional culture systems and organoid-based xenografts as new preclinical models for PDA. Copyright (c) 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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