期刊
DIABETIC MEDICINE
卷 25, 期 9, 页码 1015-1024出版社
WILEY
DOI: 10.1111/j.1464-5491.2008.02493.x
关键词
complicationis; insulin resistance; meta-analysis; metformin; Type I diabetes
资金
- Novo Nordisk
Type 1 diabetes is recognised to include an element of insulin resistance. Insulin resistance is an independent risk factor for the development of macro- and microvascular complications of Type 1 diabetes and may also contribute to the development of the disease. This understanding comes at a time when the incidence of Type 1 diabetes appears to be rising and the public health burden from its vascular complications is high. A variety of safe and efficacious manoeuvres are available to redress insulin resistance in Type 2 diabetes. So far however, clinical trials addressing insulin resistance in Type 1 diabetes have been small with only short periods of follow-up. Regardless, these trials have yielded promising results. This review examines the evidence for insulin resistance in the pathophysiology of Type I diabetes and its complications, the problems associated with its measurement, and summarizes the trials aimed at reducing insulin resistance in Type I diabetes. This includes a meta-analysis of controlled trials of adjuvant metformin in Type I diabetes.
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