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Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia
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Serum concentrations of activin and follistatin are elevated and run in parallel in patients with septicemia
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Circulating follistatin concentrations are higher and activin concentrations are lower in polycystic ovarian syndrome
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Activin A release into the circulation is an early event in systemic inflammation and precedes the release of follistatin
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