期刊
DIABETES-METABOLISM RESEARCH AND REVIEWS
卷 24, 期 8, 页码 604-610出版社
WILEY
DOI: 10.1002/dmrr.893
关键词
nanomedicine; glucose sensors; fluorescence; nanoparticles; insulin; single-molecule
资金
- Engineering and Physical Sciences Research Council
- Wellcome Trust
- Royal Society
- Wolfson Foundation
- Scottish Funding Council
- Higher Education Funding Council for England
- EPSRC [EP/D062861/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/D062861/1] Funding Source: researchfish
Nanomedicine involves measurement and therapy at the level of 1-100 nm. Although the science is still in its infancy, it has major potential applications in diabetes. These include solving needs such as non-invasive glucose monitoring using implanted nanosensors, with key techniques being fluorescence resonance energy transfer (FRET) and fluorescence lifetime sensing, as well as new nano-encapsulation technologies for sensors such as layer-by-layer (LBL) films. The latter might also achieve better insulin delivery in diabetes by both improved islet encapsulation and oral insulin formulations. An artificial nanopancreas' could be an alternative closed-loop insulin delivery system. Other applications of nanomedicine include targeted molecular imaging in vivo (e.g. tissue complications) using quantum dots (QDs) or gold nanoparticles, and single-molecule detection for the study of molecular diversity in diabetes pathology. Copyright (C) 2008 John Wiley & Sons, Ltd.
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