期刊
DIABETES RESEARCH AND CLINICAL PRACTICE
卷 97, 期 3, 页码 474-482出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2012.02.029
关键词
Resveratrol; High fat diet; Diabetes; Islet beta cell; SIRT1
资金
- Scientific and Technological Project in the Hubei province [2007AA302B05]
The aim of this study was to investigate the effect of resveratrol on beta cells in male C57BL/6J mice fed a high-fat diet and the possible mechanisms. Male C57BL/6J mice were randomly divided into three groups: normal control (NC) group, high-fat diet (HF) group and high-fat diet and resveratrol treatment (HFR) group (15 in each group). HFR group was fed with high fat diet for 8 weeks and then orally administered resveratrol at 400 mg/kg daily. Twenty-four weeks later, the function of insulin secretion in vivo and in vitro was improved robustly in HFR group compared with HF group. The levels of glucose and lipid metabolism, beta cell mass, lipid content, and oxidative stress were lower in HFR group than in HF group. Simultaneously, resveratrol administration promoted the expression of SIRT1 in islets, while the expression of uncoupling protein 2 (UCP2) was restrained. Resveratrol, as well, also had a beneficial effect on the ratios of expressions of Bcl-2/Bax and levels of mal-ondialdehyde/ glutathione peroxidase. Resveratrol can protect islets from abnormal insulin secretion and morphological changes induced by a high-fat diet. The effect might be partly related to activated SIRT1 signal pathway, improved oxidative stress induced damage and incidence of apoptosis. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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