Pegylated interferon-α2b and ribavirin combination therapy induces Hashitoxicosis followed by type 1 diabetes mellitus

The combination of pegylated interferon-alpha 2b (PEG-IFN alpha) and ribavirin (RBV) is a standard treatment for chronic hepatitis C. The case of a patient with chronic hepatitis C who developed Hashitoxicosis followed by type 1 diabetes mellitus (T1DM) with PEG-IFN alpha plus RBV combination therapy, but not IFN alpha alone, is presented. (C) 2011 Elsevier Ireland Ltd. All rights reserved.