期刊
DIABETES RESEARCH AND CLINICAL PRACTICE
卷 89, 期 3, 页码 209-215出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2010.04.018
关键词
Angiotensin receptor blocker; Hypertension; Diabetes mellitus; Inflammation; Cholesterol
资金
- Novartis Pharma GmbH, Nurnberg, Germany
- Deutsche Forschungsgemeinschaft [DFG-GK 754-III, DFG-KI 712/5-1 (FG 1054), DFG-KI 712/6-1 (KFG 218), DFG-MA 2047/4-1, DFG-WA 2145/1-1]
- Novartis-Stiftung fur therapeutische Forschung
- European Foundation for the Study of Diabetes (EFSD)
- Else Kroner-Fresenius Stiftung
Aims: The present study aimed to explore the impact of the angiotensin type 1 receptor blocker valsartan (VAL) on inflammatory-/lipid-/glucose parameters in hypertensive diabetic patients with and without coronary artery disease (CAD). Methods: This was a 16-week, randomized, double-blind, placebo-controlled two-center study with VAL 320 mg/d in 109 hypertensive diabetic patients (n = 56 non-CAD; n = 53 CAD). Results: VAL treatment did not significantly affect serum interleukin-6 (IL-6) or tumor necrosis factor alpha (TNF alpha) levels in the overall study population but significantly reduced serum IL-6 in the subgroup with high inflammatory load at baseline (IL-6 > median (2.0 ng/L), n = 54:. [median, ng/L]): VAL: from 3.5 to 2.4; placebo: from 3.2 to 3.5; p = 0.035). VAL significantly lowered total- and LDL-cholesterol in the whole study population: [median, mg/dL]: total cholesterol: VAL: from 178 to 168; placebo: from 174 to 173, p = 0.039; LDL-cholesterol: VAL: from 96 to 90, placebo: from 102 to 103, p = 0.006, whereas glycemic parameters were not affected. Conclusions: The present study demonstrates significant anti-inflammatory efficacy of VAL in hypertensive diabetic patients with enhanced inflammatory burden. High-dose VAL therapy significantly lowered total- and LDL-cholesterol levels. The combined actions of cholesterol and blood pressure lowering by VAL may provide additional clinical benefits for these high-risk patients. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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