Prevalence of insulin resistance and its relationship with cardiovascular disease risk factors among Thai adults over 35 years old

Aims: To estimate the prevalence of insulin resistance (HOMA-IR) and to study its relationship with selected cardiovascular disease risk factors among Thai adults. Methods: This cross-sectional study was comprised of 227 men and 990 women undergoing routine health check-up. The prevalence of insulin resistance was estimated using diagnostic criteria previously employed in Asian and other populations. Spearman's rank correlation coefficients were used to evaluate associations of HOMA-IR with selected cardiovascular disease risk factors. Multivariable logistic regression procedures were used to evaluate associations of hypertriglyceridemia, low HDL-Cholesterolemia, and hypertension with varying HOMA-IR values. Results: Approximately 25.1% of men (HOMA-IR >= 1.56) and 21.5% of women (HOMA-IR >= 1.64) were classified as having insulin resistance. HOMA-IR values were statistically significantly. and positively associated with body mass index, body fat percentage, waist circumference, and serum triglycerides. The values were inversely correlated with HDL-Cholesterol. When compared with those whose HOMA-IR values were within the lowest quartile (<0.45), men with HOMA-IR values in the highest quartile (>= 1.58) had higher risks of hypertriglyceridemia (adjusted OR = 2.83), low HDL-Cholesterolemia (adjusted OR = 2.79), and hypertension (adjusted OR = 2.76). Similar associations were observed among women. Conclusion: Insulin resistance, as determined using HOMA-IR, was positively associated with selected cardiovascular disease risk factors among Thai adults. (C) 2010 Elsevier Ireland Ltd. All rights reserved.