期刊
DIABETES RESEARCH AND CLINICAL PRACTICE
卷 86, 期 3, 页码 E54-E57出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2009.09.012
关键词
PTPN22; CTLA-4; Polymorphism; Type 1 diabetes
资金
- Croatian Ministry for Science, Education and Sports [098-0982464-2460, 098-0982464-2508]
In this case-control study the association between the PTPN22 1858T and CTLA-4 49G gene variants and T1D in Croatian population was examined. We found that distribution of PTPN22 C1858T and CTLA-4 A49G genotypes between T1D patient (n = 102) and control (n = 193) groups differ significantly (p < 0.0001 and p = 0.012, respectively). Moreover, although the risk alleles of both SNPs are distributed more frequently in patients, the significant difference is observed only for PTPN22 1858T allele (p < 0.0001). This is therefore the first evidence that analyzed gene variants contribute to T1D pathogenesis in Croatian population. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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