期刊
DIABETES OBESITY & METABOLISM
卷 16, 期 1, 页码 90-93出版社
WILEY-BLACKWELL
DOI: 10.1111/dom.12191
关键词
glycaemic control; low-carbohydrate diet; low-fat diet; medication therapy management; orlistat
资金
- NIH [ST32DK007012-35]
- Department of Veterans Affairs [CLIN-5-03F]
- VA Health Services Research Career Development Award [RCD02-183-1]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [T32DK007012] Funding Source: NIH RePORTER
We analysed participants with type 2 diabetes (n=46) within a larger weight loss trial (n=146) who were randomized to 48weeks of a low-carbohydrate diet (LCD; n=22) or a low-fat diet+orlistat (LFD+O; n=24). At baseline, mean body mass index (BMI) was 39.5kg/m(2) (s.d. 6.5) and haemoglobin A1c (HbA1c) 7.6% (s.d. 1.3). Although the interventions reduced BMI similarly (LCD -2.4kg/m(2); LFD+O -2.7kg/m(2), p=0.7), LCD led to a relative improvement in HbA1c: -0.7% in LCD versus +0.2% in LFD+O [difference -0.8%, 95% confidence interval (CI)=-1.6, -0.02; p=0.045]. LCD also led to a greater reduction in antiglycaemic medications using a novel medication effect score (MES) based on medication potency and total daily dose; 70.6% of LCD versus 30.4% LFD+O decreased their MES by 50% (p=0.01). Lowering dietary carbohydrate intake demonstrated benefits on glycaemic control beyond its weight loss effects, while at the same time lowering antiglycaemic medication requirements.
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