相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci
Richa Saxena et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2012)
Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets
C. Dai et al.
DIABETOLOGIA (2012)
Carbohydrate response element-binding protein (ChREBP) plays a pivotal role in beta cell glucotoxicity
N. Poungvarin et al.
DIABETOLOGIA (2012)
DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients
Michael Volkmar et al.
EMBO JOURNAL (2012)
Genetic association of Glutathione peroxidase-1 (GPx-1) and NAD(P)H:Quinone Oxidoreductase 1(NQO1) variants and their association of CAD in patients with type-2 diabetes
Tharmarajan Ramprasath et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2012)
Genome-wide identification of palmitate-regulated immediate early genes and target genes in pancreatic beta-cells reveals a central role of NF-κB
Hyung Jin Choi et al.
MOLECULAR BIOLOGY REPORTS (2012)
Association between the rs1050450 glutathione peroxidase-1 (C > T) gene variant and peripheral neuropathy in two independent samples of subjects with diabetes mellitus
T. S. Tang et al.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2012)
Analysis of Beta-Cell Gene Expression Reveals Inflammatory Signaling and Evidence of Dedifferentiation following Human Islet Isolation and Culture
Sarita Negi et al.
PLOS ONE (2012)
Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure
O. Kluth et al.
DIABETOLOGIA (2011)
Pancreatic alpha cell mass in European subjects with type 2 diabetes
J. C. Henquin et al.
DIABETOLOGIA (2011)
Decreased expression of genes involved in oxidative phosphorylation in human pancreatic islets from patients with type 2 diabetes
Anders H. Olsson et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2011)
ChREBP Mediates Glucose Repression of Peroxisome Proliferator-activated Receptor α Expression in Pancreatic β-Cells
Michael Boergesen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion
Philippe Ravassard et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Chronic Effects of Palmitate Overload on Nutrient-Induced Insulin Secretion and Autocrine Signalling in Pancreatic MIN6 Beta Cells
Maria L. Watson et al.
PLOS ONE (2011)
ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic β-cells
Gabriela da Silva Xavier et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6
Nathalie M. Fiaschi-Taesch et al.
DIABETES (2010)
Diet-induced gene expression of isolated pancreatic islets from a polygenic mouse model of the metabolic syndrome
T. Dreja et al.
DIABETOLOGIA (2010)
A genomic-based approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)γa as a pancreatic beta cell-specific biomarker
D. Flamez et al.
DIABETOLOGIA (2010)
Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes
M. Igoillo-Esteve et al.
DIABETOLOGIA (2010)
Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring
Sheau-Fang Ng et al.
NATURE (2010)
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Josee Dupuis et al.
NATURE GENETICS (2010)
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Benjamin F. Voight et al.
NATURE GENETICS (2010)
Type 2 Diabetes Susceptibility Gene Expression in Normal or Diabetic Sorted Human Alpha and Beta Cells: Correlations with Age or BMI of Islet Donors
Clare L. Kirkpatrick et al.
PLOS ONE (2010)
Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes
Lorella Marselli et al.
PLOS ONE (2010)
Expression of Reg Family Proteins in Embryonic Stem Cells and Its Modulation by Wnt/β-Catenin Signaling
Donghui Jing et al.
STEM CELLS AND DEVELOPMENT (2010)
Identification of genes selectively disallowed in the pancreatic islet
Timothy J. Pullen et al.
ISLETS (2010)
Effect of intrauterine undernutrition during late gestation on pancreatic β cell mass
Tae Inoue et al.
BIOMEDICAL RESEARCH-TOKYO (2009)
Detailed transcriptome atlas of the pancreatic beta cell
Burak Kutlu et al.
BMC MEDICAL GENOMICS (2009)
Genome-wide association studies in type 2 diabetes
Mark I. McCarthy et al.
CURRENT DIABETES REPORTS (2009)
Use of Multiple Metabolic and Genetic Markers to Improve the Prediction of Type 2 Diabetes: the EPIC-Potsdam Study
Matthias B. Schulze et al.
DIABETES CARE (2009)
β-Cell-Specific Overexpression of Glutathione Peroxidase Preserves Intranuclear MafA and Reverses Diabetes in db/db Mice
Jamie S. Harmon et al.
ENDOCRINOLOGY (2009)
Poor maternal nutrition followed by accelerated postnatal growth leads to telomere shortening and increased markers of cell senescence in rat islets
J. L. Tarry-Adkins et al.
FASEB JOURNAL (2009)
Glucose-stimulated Expression of Txnip Is Mediated by Carbohydrate Response Element-binding Protein, p300, and Histone H4 Acetylation in Pancreatic Beta Cells
Hyunjoo Cha-Molstad et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Early Low Protein Diet Aggravates Unbalance between Antioxidant Enzymes Leading to Islet Dysfunction
Nicolas Theys et al.
PLOS ONE (2009)
Quantitative proteomic analysis of single pancreatic islets
Leonie F. Waanders et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Mouse pancreatic endocrine cell transcriptome defined in the embryonic Ngn3-null mouse
Kirstine Juhl et al.
DIABETES (2008)
Lessons From the First Comprehensive Molecular Characterization of Cell Cycle Control in Rodent Insulinoma Cell Lines
Irene Cozar-Castellano et al.
DIABETES (2008)
Pancreatic β-cell mass in European subjects with type 2 diabetes
J. Rahier et al.
DIABETES OBESITY & METABOLISM (2008)
Gene expression of purified β-cell tissue obtained from human pancreas with laser capture microdissection
Lorella Marselli et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2008)
The identification of potential factors associated with the development of type 2 diabetes - A quantitative proteomics approach
Hongfang Lu et al.
MOLECULAR & CELLULAR PROTEOMICS (2008)
Obesity Upregulates Genes Involved in Oxidative Phosphorylation in Livers of Diabetic Patients
Toshinari Takamura et al.
OBESITY (2008)
A meta-analysis of QTL for diabetes-related traits in rodents
Christian Schmidt et al.
PHYSIOLOGICAL GENOMICS (2008)
Analysis of gene expression in pancreatic islets from diet-induced obese mice
Yumi Imai et al.
PHYSIOLOGICAL GENOMICS (2008)
Ex vivo transcriptional profiling of human pancreatic islets following chronic exposure to monounsaturated fatty acids
George Bikopoulos et al.
JOURNAL OF ENDOCRINOLOGY (2008)
MafA regulates expression of genes important to islet β-cell function
Taka-aki Matsuoka et al.
MOLECULAR ENDOCRINOLOGY (2007)
Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography
Masami Nemoto et al.
CARDIOVASCULAR DIABETOLOGY (2007)
Development of diabetes in obese, insulin-resistant mice:: essential role of dietary carbohydrate in beta cell destruction
H. S. Juergens et al.
DIABETOLOGIA (2007)
Sox9 coordinates a transcriptional network in pancreatic progenitor cells
F. C. Lynn et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes
D. R. Laybutt et al.
DIABETOLOGIA (2007)
Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes
H. Misu et al.
DIABETOLOGIA (2007)
The genetic landscape of type 2 diabetes in mice
Susanne M. Clee et al.
ENDOCRINE REVIEWS (2007)
Changes in gene expression in beta cells after islet isolation and transplantation using laser-capture microdissection
Y. B. Ahn et al.
DIABETOLOGIA (2007)
Novel genes identified by manual annotation and microarray expression analysis in the pancreas
Joan M. Mazzarelli et al.
GENOMICS (2006)
Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention:: follow-up of the Finnish Diabetes Prevention Study
Jaana Lindstrom et al.
LANCET (2006)
Islet inflammation and fibrosis in a spontaneous model of type 2 diabetes, the GK rat
Francoise Homo-Delarche et al.
DIABETES (2006)
The MHG box transcription factor Sox4 contributes to the development of the endocrine pancreas
ME Wilson et al.
DIABETES (2005)
Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans
DK Hagman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Differentially expressed proteins in the pancreas of diet-induced diabetic mice
LH Qiu et al.
MOLECULAR & CELLULAR PROTEOMICS (2005)
Overexpression of glutathione peroxidase with two isoforms of superoxide dismutase protects mouse islets from oxidative injury and improves islet graft function
TB Mysore et al.
DIABETES (2005)
Genetic epidemiology of diabetes
MA Permutt et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver
R Dentin et al.
BIOCHIMIE (2005)
beta-cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: A new analysis
E Ferrannini et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)
Chronic effects of fatty acids on pancreatic β-cell function -: New insights from functional genomics
TJ Biden et al.
DIABETES (2004)
Cell lines derived from pancreatic islets
HE Hohmeier et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2004)
Free fatty acids and Cytokines induce pancreatic β-cell apoptosis by different mechanisms:: Role of nuclear factor-κB and endoplasmic reticulum stress
I Kharroubi et al.
ENDOCRINOLOGY (2004)
Intracellular stress signaling pathways activated during human islet preparation and following acute cytokine exposure
S Abdelli et al.
DIABETES (2004)
Response of human islets to isolation stress and the effect of antioxidant treatment
R Bottino et al.
DIABETES (2004)
Identification of tissue-restricted transcripts in human islets
A Maffei et al.
ENDOCRINOLOGY (2004)
Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis
CL Kelpe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Transcriptional program of the endocrine pancreas in mice and humans
KH Kaestner et al.
DIABETES (2003)
Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice
RN Kulkarni et al.
DIABETES (2003)
Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic β-cell turnover and function
K Maedler et al.
DIABETES (2003)
Opposite effects of background genotype on muscle and liver insulin sensitivity of lipoatrophic mice
C Colombo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
AE Butler et al.
DIABETES (2003)
Production and characterization of Reg knockout mice -: Reduced proliferation of pancreatic β-cells in Reg knockout mice
M Unno et al.
DIABETES (2002)
Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity -: Role in β-cell adaptation and failure in the etiology of diabetes
M Prentki et al.
DIABETES (2002)
Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets:: Possible role of oxidative stress
S Piro et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2002)
Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets -: Evidence that β-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
R Lupi et al.
DIABETES (2002)
Regulation of insulin gene transcription
D Melloul et al.
DIABETOLOGIA (2002)
Functional inactivation, of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes
AM Fernández et al.
GENES & DEVELOPMENT (2001)
分享论文
