期刊
DIABETES OBESITY & METABOLISM
卷 13, 期 10, 页码 959-962出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1463-1326.2011.01426.x
关键词
adipocyte; glucose uptake; insulin resistance; skeletal muscle
资金
- Diabetes Australia Research Trust
We investigated the effects of exercise training on adipose tissue and skeletal muscle GLUT4 expression in patients with type 2 diabetes (T2D). Muscle and adipose tissue samples were obtained before and after 4-weeks of exercise training in seven patients with T2D [47 +/- 2 years, body mass index (BMI) 28 +/- 2]. Seven control subjects (54 +/- 4, BMI 30 +/- 2) were recruited for baseline comparison. Adipose tissue GLUT4 protein expression was 43% lower (p < 0.05) in patients with T2D compared with control subjects and exercise training increased (p < 0.05) adipose tissue GLUT4 expression by 36%. Skeletal muscle GLUT4 protein expression was not different between control subjects and patients with T2D. Exercise training increased (p < 0.05) skeletal muscle GLUT4 protein expression by 20%. In conclusion, 4-weeks of exercise training increased GLUT4 expression in adipose tissue and skeletal muscle of patients with T2D, although the functional benefits of this adaptation appear to be dependent on an optimal beta-cell function.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据