期刊
DIABETES OBESITY & METABOLISM
卷 10, 期 -, 页码 109-118出版社
WILEY
DOI: 10.1111/j.1463-1326.2008.00944.x
关键词
beta-cell mass; beta-cell specificity; non-invasive beta-cell imaging; radiolabelled imaging probes
资金
- MSD/EFSD
- Ruhr-University Bochum
Visualization and quantification of the native beta-cell mass in vivo in humans appear to be important in the study of the natural course of diabetes, and in ongoing trials aimed at preserving beta-cell mass in patients with diabetes. This cannot be done by biopsy sampling, and therefore there is a great need for development of a non-invasive method. This article discusses the principle theoretical requirements for reaching this goal. In addition, it provides an overview of tracer probes, which have been examined as potential beta-cell mass imaging agents in the past. Finally. some future perspectives are discussed.
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