期刊
DIABETES CARE
卷 36, 期 9, 页码 2516-2522出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc12-2606
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资金
- National Institutes of Health (NIH) [R01-DK-077966]
- Michigan Nutrition and Obesity Research Center
- Michigan Diabetes Research and Training Center
- NIH [DK-089503, DK-020572, 2UL-1TR-000433-06, P30-DK-089503]
OBJECTIVE The purpose of this study was to determine the effect of a relatively modest session of exercise on insulin sensitivity and fatty acid uptake the next day in obese adults.RESEARCH DESIGN AND METHODS Eleven sedentary obese adults (male/female: 3/8; BMI 37 +/- 1 kg/m(2); peak oxygen uptake [VO(2)peak] 20 +/- 1 mL/kg/min) completed three experimental trials. On two of these occasions, subjects exercised to expend 350 kcal in the afternoon. These two exercise trials were identical except for the exercise intensity (50% VO(2)peak [EX50] and 65% VO(2)peak [EX65]) and the duration of exercise necessary to expend 350 kcal (EX50 = approximate to 70 min; EX65 = approximate to 55 min). Subjects also completed a control trial (CON), without exercise. The next morning, we measured insulin sensitivity (hyperinsulinemic-euglycemic clamp) and whole-body fatty acid uptake (palmitate rate of disappearance from plasma [R-d]).RESULTS Exercise increased insulin sensitivity the next day, but whereas the 35% improvement after EX50 compared with CON was statistically significant (P = 0.01), the 20% improvement after EX65 was not (P = 0.17). Despite nearly identical values between CON and EX65 (P = 0.88), systemic fatty acid uptake was lower after EX50 compared with EX65 (P = 0.02), but not quite significant compared with CON (P = 0.07). Importantly, the change in fatty acid uptake after exercise compared with CON was negatively correlated with the change in insulin sensitivity for all trials (r = -0.60, P = 0.003).CONCLUSIONS A relatively modest single session of exercise in obese adults improved insulin sensitivity the next day, and a reduction in systemic fatty acid uptake in the several hours after exercise may be important for this effect.
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