期刊
DIABETES CARE
卷 36, 期 6, 页码 1695-1702出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc12-1224
关键词
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资金
- European Union from the European Regional Development Fund
- FPI grant [BES-2008-04338]
- Regional Ministry of Health of the Valencian Regional Government [CES10/030]
- Carlos III Health Institute [CP10/0360]
- [PI10/1195, PI09/01025]
- [SAF2010-16030]
- [CIBERehd CB06/04/0071]
- [PROMETEO 2010/060]
- [ACOMP/2012/042]
- [ACOMP/2012/045]
OBJECTIVE-Diabetes is associated with oxidative stress and increased mortality, but a possible correlation between leukocyte-endothelium interactions, oxidative stress, and silent myocardial ischemia (SMI) is yet to be confirmed. RESEARCH DESIGN AND METHODS-Mitochondrial dysfunction and interactions between leukocytes and human umbilical vein endothelial cells were evaluated in 200 type 2 diabetic patients (25 with SMI) and 60 body composition and age-matched control subjects. A possible correlation between these parameters and the onset of SMI was explored, and anthropometric and metabolic parameters were also analyzed. RESULTS-Waist, levels of triglycerides, proinflammatory cytokines (interleukin-6 and tumor necrosis factor-alpha, HbA(1c), high-sensitivity C-reactive protein (hs-CRP), glucose, and insulin, and homeostasis model assessment of insulin resistance were higher in diabetic patients than in control subjects. However, no statistical differences in hs-CRP and insulin levels were detected when the data were adjusted for waist. None of these parameters varied between SMI and non-SMI patients. Mitochondrial function was impaired and leukocyte-endothelium interactions were more frequent among diabetic patients, which was evident in the lower mitochondrial 02 consumption, membrane potential, polymorphonuclear cell rolling velocity, and GSH/GSSG ratio, and in the higher mitochondrial reactive oxygen species production and rolling flux, adhesion, and vascular cell adhesion molecule-1 (VCAM-1) and E-selectin molecules observed in these subjects. Moreover, these differences correlated with SMI. Statistical differences were maintained after adjusting the data for BMI and waist, with the exception of VCAM-1 levels when adjusted for waist. CONCLUSIONS-Oxidative stress, mitochondrial dysfunction, and endothelium-inducing leukocyte-endothelium interactions are features of type 2 diabetes and correlate with SMI.
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