期刊
DIABETES CARE
卷 35, 期 5, 页码 1171-1180出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc11-2055
关键词
-
资金
- NIH from National Institute on Aging [K08-AG-029813]
- National Institute of Mental Health [R01-MH-091448]
- National Heart, Lung, and Blood Institute [K99-HL-098459]
- National Institutes of Health (NIH) [R01-HL-036310, R01-AG-034454, DK-58845]
- Academy of Finland
- BUPA Foundation, U.K.
- MRC [G0902037] Funding Source: UKRI
- British Heart Foundation [RG/07/008/23674] Funding Source: researchfish
- Medical Research Council [G19/35, G0100222, G8802774, G0902037] Funding Source: researchfish
OBJECTIVE-Epidemiological studies have repeatedly investigated the association between depression and metabolic syndrome (MetS). However, the results have been inconsistent. This meta-analysis aimed to summarize the current evidence from cross-sectional and prospective cohort studies that evaluated this association. RESEARCH DESIGN AND METHODS-MEDLINE, EMBASE, and PsycINFO data-bases were searched for articles published up to January 2012. Cross-sectional and cohort studies that reported an association between the two conditions in adults were included. Data on prevalence, incidence, unadjusted or adjusted odds ratio (OR), and 95% Cl were extracted or provided by the authors. The pooled OR was calculated separately for cross-sectional and cohort studies using random-effects models. The 12 statistic was used to assess heterogeneity. RESULTS-The search yielded 29 cross-sectional studies (n = 155,333): 27 studies reported unadjusted OR with a pooled estimate of 1.42 (95% CI 1.28-1.57; I-2 = 55.1%); 11 studies reported adjusted OR with depression as the outcome (1.27 [1.07-1.57]; I-2 = 60.9%), and 12 studies reported adjusted OR with MetS as the outcome (1.34 [1.18-1.51]; I-2 = 0%). Eleven cohort studies were found (2 studies reported both directions): 9 studies (n = 26,936 with 2,316 new-onset depression case subjects) reported adjusted OR with depression as the outcome (1.49 [1.19-1.87]; I-2 = 56.8%), 4 studies (n = 3,834 with 350 MetS case subjects) reported adjusted OR with MetS as the outcome (1.52 [1.20-1.91]; I-2 = 0%). CONCLUSIONS-Our results indicate a bidirectional association between depression and MetS. These results support early detection and management of depression among patients with MetS and vice versa.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据