期刊
DIABETES CARE
卷 34, 期 7, 页码 1639-1641出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc11-0039
关键词
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资金
- European Foundation for the Study of Diabetes (EFSD)
- Bristol-Myers Squibb Company
- Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province
- National Science Foundation [30831160518]
OBJECTIVE-To determine the relationship between selected cytokines and diabetes in Chinese subjects. RESEARCH DESIGN AND METHODS-Adult patients with recent-onset type I diabetes (n = 53), latent autoimmune diabetes in adults (LADA) (n = 250), and type 2 diabetes (n = 285) from multiple centers were compared with normal subjects (n = 196). We centrally tested serum GAD antibodies (GADAs), interleukin-6 (IL-6), lipocalin 2 (LCN2), high-sensitivity C-reactive protein (hs-CRP), and adiponectin. RESULTS-After adjustment for age, sex, and BMI, all diabetes types had increased IL-6 and LCN2 (P < 0.01), and all four cytokines were increased in LADA (P < 0.01). In type 1 diabetes, adiponectin but not hs-CRP was increased (P < 0.01), whereas in type 2 diabetes, hs-CRP but not adiponectin was increased (P < 0.01). Adiponectin was correlated positively with GADA titer and negatively with hs-CRP (P < 0.01 for both). CONCLUSIONS-In China, inflammatory markers are increased in all three major types of diabetes, but probably for different reasons, even in autoimmune diabetes.
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