期刊
DIABETES CARE
卷 34, 期 10, 页码 2152-2157出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc11-0874
关键词
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资金
- Department of Health and Human Services, National Institutes of Health [DK-57136, DK-57149, DK-56990, DK-57177, DK-57171, DK-57151, DK-57182, DK-57131, DK-57002, DK-57078, DK-57154, DK-57178, DK-57219, DK-57008, DK-57135, DK-56992]
- National Institute of Diabetes and Digestive and Kidney Diseases
- The Johns Hopkins Medical Institutions Bayview General Clinical Research Center [M01RR02719]
- Johns Hopkins-University of Maryland Diabetes Research and Training Center [P60DK079637]
- Massachusetts General Hospital Mallinckrodt General Clinical Research Center [M01RR01066]
- University of Colorado Health Sciences Center General Clinical Research Center [M01RR00051]
- Clinical Nutrition Research Unit [P30 DK48520]
- University of Tennessee at Memphis General Clinical Research Center [M01RR0021140]
- University of Pittsburgh General Clinical Research Center [M01RR000056 44]
- National Institutes of Health [DK-046204]
- University of Washington/VA Puget Sound Health Care System Medical Research Service, Department of Veterans Affairs
- Frederic C. Banter General Clinical Research Center [M01RR01346]
- BodyMedia, Inc.
OBJECTIVE-Rates of severe obesity (BMI 40 kg/m(2)) are on the rise, and effective treatment options are needed. We examined the effect of an intensive lifestyle intervention (ILI) on weight loss, cardiovascular disease (CVD) risk, and program adherence in participants with type 2 diabetes who were severely obese compared with overweight (BMI 25 to <30 kg/m(2)), class I (BMI 30 to <35 kg/m(2)), and class II (BMI 35 to <40 kg/m(2)) obese participants. RESEARCH DESIGN AND METHODS-Participants in the Action for Health in Diabetes (Look AHEAD) trial were randomly assigned to ILI or diabetes support and education (DSE). DSE participants received a less intense educational intervention, whereas ILI participants received an intensive behavioral treatment to increase physical activity (PA) and reduce caloric intake. This article focuses on the 2,503 ILI participants (age 58.6 +/- 6.8 years). RESULTS-At 1 year, severely obese participants in the ILI group lost 9.04 7.6% of initial body weight, which was significantly greater (P < 0.05) than ILI participants who were overweight (-7.43 +/- 5.6%) and comparable to class I (-8.72 +/- 6.4%) and class II obese (-8.64 +/- 7.4%) participants. All BMI groups had comparable improvements in fitness, PA, LDL cholesterol, triglycerides, blood pressure, fasting glucose, and HbA(1c) at 1 year. ILI treatment session attendance was excellent and did not differ among weight categories (severe obese 80% vs. others 83%; P = 0.43). CONCLUSIONS-Severely obese participants in the ILI group had similar adherence, percentage of weight loss, and improvement in CVD risk compared with less obese participants. Behavioral weight loss programs should be considered an effective option for this population.
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