期刊
DIABETES CARE
卷 34, 期 12, 页码 2527-2529出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc11-1430
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资金
- Diabetes UK [BDA 07/003551]
- National Institute for Health Research (NIHR) [PDF/08/01/036]
- Juvenile Diabetes Research Foundation
- Abbott Diabetes Care
- Medtronic
- Roche
- Novo Nordisk
- Eli Lilly
- MDS
- Becton Dickenson
- Diabetes UK [07/0003551] Funding Source: researchfish
- Medical Research Council [G0600717B] Funding Source: researchfish
- National Institute for Health Research [PDF/01/036, NF-SI-0508-10274] Funding Source: researchfish
OBJECTIVE-To evaluate the safety and efficacy of closed-loop insulin delivery in well-controlled pregnant women with type 1 diabetes treated with continuous subcutaneous insulin infusion (CSII). RESEARCH DESIGN AND METHODS-A total of 12 women with type 1 diabetes (aged 32.9 years, diabetes duration 17.6 years, BMI 27.1 kg/m(2), and HbA(1c) 6.4%) were randomly allocated to closed-loop or conventional CSII. They performed normal daily activities (standardized meals, snacks, and exercise) for 24 h on two occasions at 19 and 23 weeks' gestation. Plasma glucose time in target (63-140 mg/dL) and time spent hypoglycemic were calculated. RESULTS-Plasma glucose time in target was comparable for closed-loop and conventional CSII (median [interquartile range]: 81 [59-87] vs. 81% [54-90]; P = 0.75). Less time was spent hypoglycemic (<45 mg/dL [0.0 vs. 0.3%]; P = 0.04), with a lower low blood glucose index (2.4 [0.9-3.5] vs. 3.3 [1.9-5.1]; P = 0.03), during closed-loop insulin delivery. CONCLUSIONS-Closed-loop insulin delivery was as effective as conventional CSII, with less time spent in extreme hypoglycemia.
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