期刊
DIABETES CARE
卷 34, 期 10, 页码 2320-2322出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc11-0775
关键词
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资金
- German Research Foundation [TH-784/2-1, TH-784/2-2]
- University of Ulm
- German Diabetes Center
- Federal Ministry of Health
- Ministry of Innovation, Science, Research, and Technology of the state North Rhine Westphalia
- Helmholtz Zentrum Munchen
- German Federal Ministry of Education and Research
OBJECTIVE-To assess the association between serum 25-hydroxyvitamin D (25-OHD) and incident type 2 diabetes and to determine whether the association is mediated by subclinical inflammation. RESEARCH DESIGN AND METHODS-Using a case-cohort design, baseline levels of 25-OHD were measured in 416 case subjects with incident type 2 diabetes and 1,267 noncase subjects selected from a source population of 7,936 middle-aged participants in the population-based Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA)/Cooperative Health Research in the Region of Augsburg (KORA) study. RESULTS-A significant inverse association was observed between serum 25-OHD and incident type 2 diabetes after adjustment for diabetes risk factors and season. The hazard ratio (HR) and 95% CI comparing tertile extremes was 0.63 (0.44-0.90) (P-trend = 0.010). Further adjustment for C-reactive protein, interleukin-6, soluble intercellular adhesion molecule-1, and interferon-gamma-inducible protein-10 attenuated this association by 16% (HR 0.7310, [0.50-1.05], P = 0.090). CONCLUSIONS-Vitamin D status is inversely related to type 2 diabetes risk and our data suggest that this association may be partially mediated by subclinical inflammation.
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