期刊
DIABETES CARE
卷 34, 期 12, 页码 2545-2547出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc11-0107
关键词
-
资金
- European Science Foundation
- Finnish Academy
- Sigrid Juselius Foundation
- Folkhalsan Research Foundation
- Nordic Center of Excellence in Disease Genetics
- Signe and Ane Gyllenberg Foundation
- Swedish Cultural Foundation in Finland
- Finnish Diabetes Research Foundation
- Foundation for Life and Health in Finland
- Finnish Medical Society
- Finnish Ministry of Education
- Paavo Nurmi Foundation
- Perklen Foundation
- Ollqvist Foundation
- Narpes Health Care Foundation
- Municipal Health Care Center
- Hospital in Jakobstad
- Health Care Center in Vasa
- Health Care Center in Narpes
- Health Care Center in Korsholm
- Lilly
- Novartis
OBJECTIVE-Although insulin resistance (IR) may underlie associations between depressive symptoms and diabetes, previous findings have been contradictory. We examined whether depressive symptoms associate with IR and insulin secretion, and, additionally, whether antidepressant medication use may modulate such associations. RESEARCH DESIGN AND METHODS-A total of 4,419 individuals underwent an oral glucose tolerance test (OGTT). Participants with previously or newly diagnosed diabetes are excluded from this sample. The homeostasis model assessment of IR (HOMA-IR) and corrected insulin response (CIR) were calculated. Depressive symptoms and antidepressant medication use were self-reported. RESULTS-After controlling for confounding factors, depressive symptoms were associated with higher fasting and 30-mM insulin during the OGTT and higher HOMA-IR but not CIR. Antidepressant medication use failed to modify these associations. CONCLUSIONS-Depressive symptoms are associated with IR but not with changes in insulin response when corrected for IR in individuals without previously or newly diagnosed diabetes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据