期刊
DIABETES CARE
卷 34, 期 2, 页码 485-490出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc10-0760
关键词
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资金
- National Cancer Institute, University of Southern California Center for Transdisciplinary Research on Energetics and Cancer [U54 CA 116848]
- National Institute of Child Health and Human Development [R01-HD/HL-33064]
- Dr. Robert C. and Veronica Atkins Foundation
- National Center for Research Resources/National Institutes of Health [M01-RR-00043]
- Swiss National Science Foundation [PBLA33-122719]
- National Cancer Institute [T32-CA-09492]
- Swiss National Science Foundation (SNF) [PBLA33-122719] Funding Source: Swiss National Science Foundation (SNF)
OBJECTIVE-Visceral adipose tissue (VAT) and hepatic fat are associated with insulin resistance and vary by sex and ethnicity. Recently, pancreatic fat fraction (PFF) has also been linked with increasing obesity. Our aim was to assess ethnic and sex differences in PFF and its relationship to other fat depots, circulating free fatty acids (FFA), insulin secretion and sensitivity, and inflammation in obese adolescents and young adults. RESEARCH DESIGN AND METHODS-We examined 138 (40 males, 98 females) obese Hispanics and African Americans (13-25 years). Subcutaneous adipose tissue and VAT volumes, hepatic fat fraction (HFF), and PFF were determined by magnetic resonance imaging. Insulin sensitivity and beta-cell function were assessed during an intravenous glucose tolerance test. RESULTS-Hispanics had higher PFF than African Americans (7.3 +/- 3.8 vs. 6.2 +/- 2.6%, P = 0.03); this ethnic difference was higher in young adults compared with children and adolescents (ethnicity X age: P = 0.01). Males had higher PFF than females (P < 0.0001). PFF was positively correlated with VAT (r = 0.45, P < 0.0001), HFF (r = 0.29, P < 0.0001), and FFA (r = 0.32, P = 0.001). PFF positively correlated with inflammatory markers but lost significance when adjusted for VAT. In multiple stepwise regression analysis, VAT and FFA were the best predictors of PFF (adjusted R-2 = 0.40). There were no significant correlations between PFF and markers of insulin sensitivity or beta-cell function. CONCLUSIONS-PFF is higher in Hispanics than African Americans, and this difference increases with age. In young obese individuals, PFF is related to VAT, HFF, and circulating FFA, thus possibly contributing to their increased risk for type 2 diabetes and related metabolic disorders.
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