期刊
DIABETES CARE
卷 34, 期 12, 页码 2567-2569出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc11-1406
关键词
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资金
- Juvenile Diabetes Research Foundation (JDRF) [1-2005-362]
- JDRF Center [4-2007-1065]
- National Institutes of Health (NIH) [1R21-DK-077580-01]
- NIH/National Center for Research Resources Clinical and Translational Science [UL1-RR029890]
OBJECTIVE-We conducted an open-label, phase I study using autologous umbilical cord blood (UCB) infusion to ameliorate type 1 diabetes (T1D). Having previously reported on the first 15 patients reaching 1 year of follow-up, herein we report on the complete cohort after 2 years of follow-up. RESEARCH DESIGN AND METHODS-A total of 24 T1D patients (median age 5.1 years) received a single intravenous infusion of autologous UCB cells and underwent metabolic and immunologic assessments. RESULTS-No infusion-related adverse events were observed. beta-Cell function declined after UCB infusion. Area under the curve C-peptide was 24.3% of baseline 1 year postinfusion (P < 0.001) and 2% of baseline 2 years after infusion (P < 0.001). Flow cytometry revealed increased regulatory T cells (Tregs) (P = 0.04) and naive Tregs (P = 0.001) 6 and 9 months after infusion, respectively. CONCLUSIONS-Autologous UCB infusion in children with T1D is safe and induces changes in Treg frequency but fails to preserve C-peptide.
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