期刊
DIABETES CARE
卷 33, 期 9, 页码 2062-2064出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc09-2188
关键词
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资金
- Academy of Finland
- Sigrid Juselius Foundation
- Finnish Diabetes Research Foundation
- Folkhalsan Research Foundation
- Wilhelm and Else Stockmann Foundation
- Finska Lakaresallskapet
- Novo Nordisk Foundation
- Swedish Cultural Foundation in Finland
- Ollquist Foundation
- Korsholm, Malax, Names, and Vasa Heath Care Centers
- Helsinki University Central Hospital
OBJECTIVE- We studied differences between patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes, and classical type 1 diabetes diagnosed after age 35 years. RESEARCH DESIGN AND METHODS- Polymorphisms in HLA-DQB1, INS, PTPN22, and CTLA4 were genotyped in patients with LADA (n = 213), type 1 diabetes diagnosed at >35 years of age (T1D(>35y); n = 257) or <20 years of age (T1D(<20y); n = 158), and type 2 diabetes. RESULTS- Although patients with LADA had an increased frequency of HLA-DQB1 and PTPN22 risk genotypes and alleles compared with type 2 diabetic subjects, the frequency was significantly lower compared with T1D(>35y) patients. Genotype frequencies, measures of insulin secretion, and metabolic traits within LADA differed according to GAD antibody (GADA) quartiles, but even the highest quartile differed from type 1 diabetes. Having two or more risk genotypes was associated with lower C-peptide concentrations in LADA. CONCLUSIONS- LADA patients differed genetically and phenotypically from both T1D(>35y) and type 2 diabetic patients in a manner dependent on GADA levels.
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