期刊
DIABETES CARE
卷 33, 期 9, 页码 2021-2023出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc10-0790
关键词
-
资金
- National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Office of the Director [R01-DK-76092, R01-DK-79003]
- National Institutes of Health Office of Dietary Supplements [R01-DK-76092, R01-DK-79003]
- National Institute of Diabetes and Digestive and Kidney Diseases [R21-DK-78867, R01-DK-58845]
- U.S. Department of Agriculture [58-1950-9001]
OBJECTIVE - To determine the association between 25-hydroxyvitamin D (25-OHD) concentration and risk of incident type 2 diabetes. RESEARCH DESIGN AND METHODS - In a nested case-control study conducted among 608 women with newly diagnosed type 2 diabetes and 559 control subjects in the Nurses' Health Study, we measured the association between baseline plasma 25-OHD concentration and risk of incident diabetes. RESULTS - After adjusting for matching factors and diabetes risk factors, including BMI, higher levels of plasma 25-OHD were associated with a lower risk for type 2 diabetes. The odds ratio for incident type 2 diabetes in the top (median 25-OHD, 33.4 ng/ml) versus the bottom (median 25-OHD, 14.4 ng/ml) quartile was 0.52 (95% Cl 0.33-0.83). The associations were consistent across subgroups of baseline BMI, age, and calcium intake. CONCLUSIONS - Plasma 25-OHD concentration was associated with lower risk of incident type 2 diabetes in women.
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