期刊
DIABETES CARE
卷 33, 期 9, 页码 1954-1956出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc10-0320
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-
资金
- Merck Sharp & Dohme (Italia) SpA, Rome, Italy
OBJECTIVE - To assess the effects of inhibited gastrointestinal cholesterol absorption in statin-treated dyslipidemic patients. RESEARCH DESIGN AND METHODS - In a multicenter prospective randomized double-blind placebo-controlled trial, we primarily compared by ANCOVA the effect of 2-month ezetimibe (10 mg/day) or placebo therapy on LDL cholesterol serum levels in 108 type 2 diabetic patients with albuminuria <200 mu g/min and total cholesterol concentrations > 135 mg/dl despite simvastatin treatment (40 mg/day). RESULTS - Unlike placebo, ezetimibe decreased LDL cholesterol from 99 +/- 31 to 66 +/- 22 mg/dl, total cholesterol from 162 +/- 36 to 124 +/- 30 mg/dl, and apolipoprotein B from 83 +/- 22 to 64 +/- 18 mg/dl (P < 0.0001 for all changes versus placebo). A total of 72 and 17% of patients on ezetimibe or placebo achieved LDL levels <70 mg/dl, respectively (P < 0.0001). Treatment was well tolerated. CONCLUSIONS - Adding ezetimibe to simvastatin therapy helps to improve the proatherogenic lipoprotein profile in type 2 diabetic patients who fail to reach recommended lipid targets with statin therapy alone.
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