期刊
DIABETES CARE
卷 32, 期 10, 页码 1823-1825出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc09-0477
关键词
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资金
- British Regional Heart Study (BRHS)
- British Heart Foundation [PG97012, PG97027]
- Diabetes U.K.
- British Heart Foundation [RG/08/013/25942] Funding Source: researchfish
OBJECTIVE - To examine the relationship between dietary fiber and the risk of type 2 diabetes in older men and the role of hepatic and inflammatory markers. RESEARCH DESIGN AND METHODS - The study was performed prospectively and included 3,428 nondiabetic men (age 60-79 years) followed up for 7 years, during which there were 162 incident cases of type 2 diabetes. RESULTS - Low total dietary fiber (lowest quartile <= 20 g/day) was associated With increased risk of diabetes after adjustment for total caloric intake and potential confounders (relative risk - 1.47 [95% CI 1.03-2.11]). This increased risk was seen separately for both low cereal and low vegetable fiber intake. Dietary fiber was inversely associated with inflammatory markers (C-reactive protein, interleukin-6) and with tissue plasminogen activator and gamma-glutamyl transferase. Adjustment for these markers attenuated the increased risk (1.28 [0.88-1.86]). CONCLUSIONS - Dietary fiber is associated with reduced diabetes risk, which may be partly explained by inflammatory markers and hepatic fat deposition.
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