期刊
DIABETES CARE
卷 32, 期 12, 页码 2230-2235出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc09-0132
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资金
- Medical Research Council
- Economic and Social Research Council
- British Heart Foundation
- Health and Safety Executive
- Department of Health
- National Institutes of Health National Heart Lung and Blood institute [HL36310]
- National Institute on Aging [AG13196]
- Agency for Health Care Policy Research [HS06516]
- John D. and Catherine T. MacArthur Foundation Research
- British Heart Foundation [RG/07/008/23674] Funding Source: researchfish
- Medical Research Council [G0501184, G0100222, G19/35, G8802774] Funding Source: researchfish
- MRC [G0501184] Funding Source: UKRI
OBJECTIVE - To investigate the effect of psychosocial stress at work on risk of type 2 diabetes, adjusting for conventional risk factors, among a sample of British, white-collar, middle-aged men and women. RESEARCH DESIGN AND METHODS - This was a prospective analysis (19912004) from the Whitehall 11 cohort study. The current sample consists of 5,895 Caucasian middle-aged civil servants free from diabetes at baseline. Type 2 diabetes was ascertained by an oral glucose tolerance test supplemented by self-reports at baseline and four consecutive waves of data collection including two screening phases. The job strain and iso-strain models were used to assess psychosocial work stress. RESULTS - iso-strain in the workplace was associated with a twofold higher risk of type 2 diabetes in age-adjusted analysis in women but not in men (hazard ratio 1.94 [95% CI 1.17-3.21]). This effect remained robust to adjustment for socioeconomic position and outside work stressors and was only attenuated by 20% after adjustment for health behaviors, obesity, and other type 2 diabetes risk factors. CONCLUSIONS - Psychosocial work stress was an independent predictor of type 2 diabetes among women after a 15-year follow-up. This association was not explained by potential confounding and mediating factors. More evidence from prospective studies using the same work stress models is needed to support the current findings and provide further information on sex differences.
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