期刊
DIABETES CARE
卷 32, 期 5, 页码 900-902出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc08-2240
关键词
-
资金
- NIDDK NIH HHS [P30 DK072476, P30-DK-072476] Funding Source: Medline
OBJECTIVE- We hypothesized that, compared with obese subjects, patients With type 2 diabetes have a lower total adipocyte number with fewer small adipocytes. RESEARCH DESIGN AND METHODS- Abdominal subcutaneous adipose tissue was obtained from lean and obese subjects with or Without type 2 diabetes matched for BMI. Adipocyte size was measured by osmium fixation and sizing/counting in a Coulter Counter. Adipocyte size and number subdistributions (small, medium, large, and very large) were determined. RESULTS- Compared with obese subjects, type 2 diabetic patients had larger mean adipocyte size and 67% bigger very large adipocytes; the total adipocyte number was lower, but the fraction of small adipocytes was increased by 27%. CONCLUSIONS- Total adipocyte cellularity is lower in type 2 diabetic subjects than in obese subjects. We found no evidence for depletion of small adipocytes in patients with type 2 diabetes. This suggests the presence of a defect in early maturation of adipocytes in patients with type 2 diabetes.
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