期刊
DIABETES CARE
卷 31, 期 7, 页码 1392-1396出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc07-2210
关键词
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资金
- NIDDK NIH HHS [R01 DK032493, R37 DK032493, DK-32493] Funding Source: Medline
- PHS HHS [432/CCU800 435-01] Funding Source: Medline
- NCCDPHP CDC HHS [00097/DP-05-069, U01 DP000247] Funding Source: Medline
OBJECTIVE - Type I diabetes is associated with a wide spectrum of susceptibility and protective genotypes within the HLA class II system. It has been reported that adults diagnosed with youth-onset type I diabetes more recently have been found to have fewer classical high-risk HLA class II genotypes than those diagnosed several decades ago. We hypothesized that such temporal trends in the distribution of HLA-DR, DQ genotypes would be evident, and perhaps even stronger, among 5- to 17-year-old Hispanic and non-Hispanic white (NHW) youth diagnosed with type 1 diabetes in Colorado between 1978 and 2004. RESEARCH DESIGN AND METHODS - HLA-DR, DQ was typed using PCR and sequence-specific oligonucleotide hybridization in 100 youth diagnosed during the period of 1978-1988 and 264 diagnosed during 2002-2004. Logistic regression was used to adjust for confounders and assess temporal trends. RESULTS - The frequency of the highest-risk genotype (DRB1*03-DQB1*02/DRB1*04-DQB1*03) was higher (39%) in children diagnosed during the period 1978-1988 than in those diagnosed during 2002-2004 (28%). A similar pattern was observed in NHWs and Hispanics. CONCLUSIONS - We found that high-risk HLA genotypes are becoming less frequent over time in youth with type I diabetes of NHW and Hispanic origin. This temporal trend may suggest that increasing environmental exposure is now able to trigger type I diabetes in subjects who are less genetically susceptible.
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