期刊
DIABETES & VASCULAR DISEASE RESEARCH
卷 11, 期 5, 页码 324-334出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1479164114535943
关键词
Matrix metalloproteinase; type 2 diabetes; exercise; extracellular matrix; capillary basement membrane
资金
- Novo Nordisk Foundation
- Danish Diabetes Association
- Danish Heart Foundation
- Jacob Madsen and Olga Madsen's Foundation
- Danish National Research Council
- Aase and Ejnar Danielsens Foundation
- Faculty of Health Sciences, University of Copenhagen
- Foundation of 1870
Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMP) play a critical role during vascular remodelling, in both health and disease. Impaired MMP regulation is associated with many diabetes-related complications. This study examined whether exercise-induced regulation of MMPs is maintained in the skeletal muscle of patients with uncomplicated type 2 diabetes (T2DM). Subjects [12 T2DM, 9 healthy control subjects (CON)] underwent 8 weeks of physical training. Messenger RNA (mRNA) was measured at baseline, during and after 8 weeks of training. Protein was measured pre- and post-training. At baseline, there were no effects of diabetes on MMP or TIMP mRNA or protein. mRNA and protein response to training was similar in both groups, except active MMP-2 protein was elevated post training in T2DM only. Our results indicate that exercise-induced stimulation of MMPs is preserved in skeletal muscle of patients with T2DM. This early stage of diabetes may provide an opportunity for intervention and prevention of complications.
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