期刊
DIABETES & VASCULAR DISEASE RESEARCH
卷 7, 期 2, 页码 158-166出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1479164109360470
关键词
arteries; type 1 diabetes; endothelium; flow-mediated dilatation; elasticity
资金
- Agence Francaise de Securite Sanitaire des Aliments et des Produits de Sante (AFSSAPS)
Flow-mediated dilatation evaluation using hand skin heating may possibly be more accurate than post-ischaemic hyperaemia to detect conduit artery endothelial dysfunction in type 1 diabetes. We measured in 24 type 1 diabetic patients (n=16 without microangiopathy) and 24 healthy matched subjects radial artery diameter (echotracking), blood flow and mean wall shear stress during heating and post-ischaemic hyperaemia. Compared with controls, flow-mediated dilatation was lower in diabetic patients during post-ischaemic hyperaemia and heating. However, in the subgroup of uncomplicated patients, a decreased flow-mediated dilatation was only apparent during heating (17.1 +/- 1.6% vs. 24.3 +/- 0.7%, p < 0.05) but not during post-ischaemic hyperaemia (10.1 +/- 1.1% vs. 10.5 +/- 0.6%, NS). This was confirmed by the lower slope of the diameter-mean wall shear stress relationship in these patients in the absence of modification in endothelium-independent dilatation. We conclude that hand skin heating permits the early detection of conduit artery endothelial dysfunction in type 1 diabetic patients with normal response to post-ischaemic hyperaemia. This procedure could be useful to investigate the prognostic role of vascular dysfunction and the impact of vasculoprotective treatments in this patient population.
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