期刊
DIABETES & METABOLISM
卷 37, 期 5, 页码 426-431出版社
MASSON EDITEUR
DOI: 10.1016/j.diabet.2011.02.002
关键词
Type 1 diabetes; Pregnancy; Continuous subcutaneous insulin infusion; Multiple daily injections; Glargine
Aim. - The best way to treat pregnant patients who have type 1 diabetes is still unclear. For this reason, the present study compared metabolic control and maternal-fetal outcomes in patients treated with continuous subcutaneous infusions of rapid-acting insulin analogues (CSII) or with insulin glargine and multiple daily injections of rapid-acting insulin analogues (glargine-MDI). Methods. - This retrospective multicentre study involved 144 women with type I diabetes, 100 of whom were using CSII and 44 glargine-MDI. Outcomes analyzed were metabolic control, diabetes complications, pregnancy outcome, perinatal morbidity and mortality, and fetal malformations. Results. - The two groups were comparable for age, prepregnancy BMI, primiparous rate and diabetes complications, although patients using CSII had longer duration of diabetes (P = 0.03) and higher White classifications (P = 0.04). In both groups, metabolic control improved during pregnancy, but good control was reached earlier among patients using CSII. At parturition, patients using CSII had lower HbA(1c) (6.2 +/- 0.7% vs 6.5 0.8%; P = 0.02) and required less insulin (P < 0.01). Weight gain was similar in both groups, and maternal-fetal outcomes did not differ. Conclusion. - In pregnant patients with type 1 diabetes, MDI and CSII are equivalent in terms of metabolic control and fetal-maternal outcomes, although patients using CSII achieved good control earlier and with less insulin. (C) 2011 Elsevier Masson SAS. All rights reserved.
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