期刊
DIABETES
卷 61, 期 6, 页码 1372-1380出版社
AMER DIABETES ASSOC
DOI: 10.2337/db11-1355
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资金
- Academy of Finland
- Academy of Finland Center of Excellence in Complex Disease Genetics
- Instrumentarium Science Foundation
- Sigrid Juselius Foundation
- Paulo Foundation
- Finnish Foundation for Cardiovascular Research
- Emil Aaltonen Foundation
- Paavo Nurmi Foundation
- Jenny and Antti Wihuri Foundation
- Juho Vainio Foundation
- Finnish Cultural Foundation
- Social Insurance Institution of Finland
- European Community
- National Heart, Lung, and Blood Institute through STAMPEED [5R01-HL-087679-02]
- National Institutes of Health/National Institute of Mental Health [5R01-MH-63706-02]
- ENGAGE
- Medical Research Council, U.K.
- Oulu University Hospital
- Kuopio University Hospital
- Tampere University Hospital
- Turku University Hospital
- [HEALTH-F4-2007-201413]
- Medical Research Council [G0801056B] Funding Source: researchfish
Metabolite associations with insulin resistance were studied in 7,098 young Finns (age 31 +/- 3 years; 52% women) to elucidate underlying metabolic pathways. Insulin resistance was assessed by the homeostasis model (HOMA-IR) and circulating metabolites quantified by high-throughput nuclear magnetic resonance spectroscopy in two population-based cohorts. Associations were analyzed using regression models adjusted for age, waist, and standard lipids. Branched-chain and aromatic amino acids, gluconeogenesis intermediates, ketone bodies, and fatty acid composition and saturation were associated with HOMA-IR (P < 0.0005 for 20 metabolite measures). Leu, Ile, Val, and Tyr displayed sex- and obesity-dependent interactions, with associations being significant for women only if they were abdominally obese. Origins of fasting metabolite levels were studied with dietary and physical activity data. Here, protein energy intake was associated with Val, Phe, Tyr, and Gln but not insulin resistance index. We further tested if 12 genetic variants regulating the metabolites also contributed to insulin resistance. The genetic determinants of metabolite levels were not associated with HOMA-IR, with the exception of a variant in GCKR associated with 12 metabolites, including amino acids (P < 0.0005). Nonetheless, metabolic signatures extending beyond obesity and lipid abnormalities reflected the degree of insulin resistance evidenced in young, normoglycemic adults with sex-specific fingerprints. Diabetes 61:1372-1380, 2012
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