期刊
DIABETES
卷 57, 期 6, 页码 1584-1594出版社
AMER DIABETES ASSOC
DOI: 10.2337/db07-1369
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资金
- NIDDK NIH HHS [DK077967, DK059579, R01 DK059579, R01 DK077967] Funding Source: Medline
OBJECTIVE-Little is known about the capacity, mechanisms, or timing of growth in beta-cell mass in humans. We sought to establish if the predominant expansion of beta-cell mass in humans occurs in early childhood and if, as in rodents, this coincides with relatively abundant beta-cell replication. We also sought to establish if there is a secondary growth in beta-cell mass coincident with the accelerated somatic growth in adolescence. RESEARCH DESIGN AND METHODS-To address these questions, pancreas volume was determined from abdominal computer tomographies in 135 children aged 4 weeks to 20 years, and morphometric analyses were performed in human pancreatic tissue obtained at autopsy from 46 children aged 2 weeks to 21 years. RESULTS-We report that 1) beta-cell mass expands by several-fold from birth to adulthood, 2) islets grow in size rather than in number during this transition, 3) the relative rate of beta-cell growth is highest in infancy and gradually declines thereafter to adulthood with no secondary accelerated growth phase (luring adolescence, 4) beta-cell mass (and presumably growth) is highly variable between individuals, and 5) a high rate of beta-cell replication is coincident with the major postnatal expansion of beta-cell mass. CONCLUSIONS-These data imply that regulation of beta-cell replication during infancy plays a major role in beta-cell mass in adult humans.
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