期刊
DIABETES
卷 57, 期 12, 页码 3289-3296出版社
AMER DIABETES ASSOC
DOI: 10.2337/db08-0787
关键词
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资金
- National Heart, Lung, and Blood Institute [Hl-47887, Hl-47889, Hl-47890, Hl-47892, Hl-47902, Hl-55208, R01-Hl-58329]
- National Center for Research Resources General Clinic Research Centers Program [M01 RR431, M01 RR01346]
- Mike Rosenbloom Foundation
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR001346] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [U01HL055208, U01HL047902, U01HL047892, U01HL047890, U01HL047889, U01HL047887, R01HL058329] Funding Source: NIH RePORTER
OBJECTIVE-TO Understand why atherogenic risk differs more between diabetic and nondiabetic Women than between diabetic and nondiabetic men. RESEARCH DESIGN AND METHODS AND RESULTS-Measures of cardiovascular risk, body composition, and serum hormones from the baseline examinations of the Insulin Resistance Atherosclerosis Study off 524 nondiabetic women, 258 diabetic women, 421 nondiabetic men, and 220 diabetic men were compared to detect greater adverse differences in women than in men. Systolic blood pressure; apolipoprotein B (apoB)., total cholesterol; apoB-to-apoA-I ratio; non-HDL cholesterol; LDL particle count, small LDL, and intermediate-density lipoprotein by nuclear magnetic resonance; and C-reactive protein exhibited significant diabetes-sex interaction (P < 0.05). ApoB exhibited the most significant interaction (P = 0.0005). Age- and ethnicity-adjusted apoB means Were lower in nondiabetic women than nondiabetic men (102.4 vs. 106.8 mg/dl, P < 0.05) but higher in diabetes (115.7 vs. 110.2 mg/dl, P < 0.01). Plotted against. BMI, waist circumference was 6% higher and hip circumference 10% lower in diabetic than nondiabetic women (both P < 0.05), whereas the circumference measures did not differ conspicuously between diabetic and nondiabetic men. CONCLUSIONS-In diabetic women, an elevated level of atherogenic particles, as manifested by apoB and LDL particle count, which may result from abdominal adiposity, represents a major treatable cardiovascular risk factor. Diabetes 57:32893296,2008
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