期刊
DEVELOPMENTAL PSYCHOBIOLOGY
卷 61, 期 5, 页码 679-687出版社
WILEY
DOI: 10.1002/dev.21765
关键词
development; early-life stress; maternal separation; microbiota-gut-brain axis; probiotic treatment; puberty; rats; rodents
资金
- Australian Research Council [DP150104835]
- University of New South Wales
- National Health and Medical Research Council [APP1031688]
- Petre Foundation
Puberty marks the beginning of a period of dramatic physical, hormonal, and social change. This instability has made adolescence infamous as a time of storm and stress and it is well-established that stress during adolescence can be particularly damaging. However, prior stress may also shape the adolescent experience. In the present series of experiments, we observed sex-specific effects of early-life maternal separation stress on the timing of puberty onset in the rat. Specifically, stressed females exhibited earlier pubertal onset compared to standard-reared females, whereas stressed males matured later than their standard-reared counterparts. Further, we demonstrated that a probiotic treatment restores the normative timing of puberty onset in rodents of both sexes. These results are in keeping with previous findings that probiotics reverse stress-induced changes in learned fear behaviors and stress hormone levels, highlighting the remarkable and wide-ranging restorative effects of probiotics in the context of early-life stress.
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