期刊
DEVELOPMENTAL PSYCHOBIOLOGY
卷 56, 期 4, 页码 797-811出版社
WILEY
DOI: 10.1002/dev.21149
关键词
saliva; serum; cytokines; immune markers; adolescent
资金
- Rubicon award from the Netherlands Organization for Scientific Research [446-10-026]
- National Institutes of Health [R01 DA16402, R21 DA025312]
- National Center for Advancing Translational Sciences, National Institutes of Health [8 UL1 TR000077-04]
- National Center for Research Resources
Theoretically, the measurement of cytokines in saliva may have utility for studies of brain, behavior, and immunity in youth. Cytokines in saliva and serum were analyzed across three annual assessments in healthy adolescent girls (N=114, 11-17 years at enrollment). Samples were assayed for GM-CSF, IFN, IL-1, IL-2, IL-6, IL-8, IL-10, IL-12p70, TNF, adiponectin, and cotinine. Results revealed: (1) cytokine levels, except IFN and IL-10, were detectable in saliva, and salivary levels, except IL-8 and IL-1, were lower than serum levels; (2) salivary cytokine levels were lower in older girls and positively associated with adiponectin; (3) compared to serum levels, the correlations between salivary cytokines were higher, but salivary cytokines were less stable across years; and (4) except for IL-1, there were no significant serum-saliva associations. Variation in basal salivary cytokine levels in healthy adolescent girls reflect compartmentalized activity of the oral mucosal immune system, rather than systemic cytokine activity. (c) 2013 Wiley Periodicals, Inc. Dev Psychobiol 56: 797-811, 2014.
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