期刊
DEVELOPMENTAL PSYCHOBIOLOGY
卷 56, 期 4, 页码 611-621出版社
WILEY
DOI: 10.1002/dev.21127
关键词
adolescent; sex; learning; extinction; reward devaluation; rat; Pavlovian approach; reacquisition; reward processing
资金
- National Institute on Drug Abuse [R01 DA029815]
Compared to adults, adolescents are at heightened risk for drug abuse and dependence. One of the factors contributing to this vulnerability may be age-dependent differences in reward processing, with adolescents approaching reward through stimulus-directed, rather than goal-directed, processes. However, the empirical evidence for this in rodent models of adolescence, particularly those that investigate both sexes, is limited. To address this, male and female rats that were adolescents (P30) or adults (P98) at the start of the experiment were trained in a Pavlovian approach (PA) task and were subsequently tested for the effects of reward devaluation, extinction, and re-acquisition. We found significant interactions between age and sex: females had enhanced acquisition of PA and poorer extinction, relative to males, while adolescents and females were less sensitive to reward devaluation than male adults. These results suggest that females and adolescents exhibit reward behavior that is more stimulus-directed, rather than goal-directed. (c) 2013 Wiley Periodicals, Inc. Dev Psychobiol 56: 611-621, 2014.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据