期刊
DEVELOPMENTAL PSYCHOBIOLOGY
卷 54, 期 5, 页码 546-555出版社
WILEY
DOI: 10.1002/dev.20613
关键词
rhesus monkey; early experience; human intruder; affective behavior; adult; lifespan
资金
- Translational Center for Neurobehavioral Alcohol Research [AA017056]
- NIH [MH084980, AA013995, AA014106]
Adverse early experiences are associated with a range of deleterious health outcomes in humans, including higher risk for affective disorders. Studies using a long-standing model of nonhuman primate model of early adversity have demonstrated that nursery-reared (NR) monkeys exhibit alterations in multiple aspects of biobehavioral development; however, few studies have evaluated the persistence of socioaffective behavioral changes through adulthood. We evaluated the effects of early rearing experience on adult animals' response to a well-validated assessment of anxiety-like behavior, the human intruder paradigm (HIP). We tested 22 rhesus monkeys who were either nursery-reared (NR) or reared with their mothers (mother-reared; MR). NR monkeys were inhibited in their behavior compared to MR monkeys, with reduced locomotion and exploratory behaviors. NR animals showed a marginal increase in freezing. Together these findings demonstrate that the consequences of differential infant rearing experience on socioaffective behavior persist into adulthood, with evidence of greater inhibition in NR monkeys. (c) 2011 Wiley Periodicals,Inc. Dev Psychobiol 54: 546555, 2012.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据