期刊
DEVELOPMENTAL PSYCHOBIOLOGY
卷 52, 期 3, 页码 225-235出版社
WILEY
DOI: 10.1002/dev.20447
关键词
adolescence; brain; development; genetics; mouse; imaging; environment
资金
- NIMH [1R01 MH73175, P50 MH62196]
- NIDA [R01 DA018879]
- Mortmer D. Stickler family
- Dewitt-Wallace fund
- Weill Cornell Medical College Citigroup Biomedical Imaging Center and Imaging Core
The characterization of adolescence as a time of storm and stress remains an open debate. Intense and frequent negative affect during this period has been hypothesized to explain the increased rates of affective disorders, suicide, and accidental death during this time of life. Yet some teems: emerge from adolescence with minimal turmoil. We provide a neurobiological model of adolescence Mat proposes an imbalance in the development of subcortical limbic (e.g., amygdala) relative to prefrontal cortical regions as a potential mechanism for heightened emotionality during this period. Empirical support for this model is provided from recent behavioral and human imaging studies on the development of emotion regulation. We then provide examples of environmental factors that may exacerbate imbalances in amygdala-ventrofrontal function increasing risk for anxiety related behaviors. Finally we present data from human and mouse studies to illustrate how genetic factors may enhance or diminish this risk. Together these studies provide a converging methods approach for understanding the highly variable :stress and turmoil experienced in adolescence. (C) 2010 Wiley Periodicals, Inc. Dev Psychobiol 225-235, 7010.
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