期刊
DEVELOPMENTAL PSYCHOBIOLOGY
卷 52, 期 6, 页码 545-557出版社
WILEY
DOI: 10.1002/dev.20460
关键词
ethanol; LiCl; taste aversion; disgust reactions; infant rat
资金
- NIAAA [AA11960, AA013098, AA015992]
- NIMH [MH035219]
- Agenda Nacional de Promocion Cientifica y Tecnologica [PICT 05-14024]
- Ministerio de Educacion y Ciencia, Spain
- PRH-UNC (FONCyT-SPU)
- CONICET (Argentina)
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH035219, R37MH035219] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R01AA011960, R01AA015992, P50AA017823, R01AA013098] Funding Source: NIH RePORTER
Adult ails display taste avoidance and disgust reactions when stimulated with gustatory stimuli previously paired with aversive agents such as lithium chloride (LiCl) By the second postnatal week of life, preweanling rats also display specific behaviors in response to a tastant conditioned stimulus (CS) that predicts LICI-induced malaise The present study compared conditioned disgust reactions induced by LiCl or ethanol (EtOH) in preweanling rats In Experiment I we determined doses of ethanol and LiCl that exert similar levels of conditioned taste avoidance. After having equated drug dosage in terms of conditioned taste avoidance, 13-day-old rats were given a single pairing of a novel taste (saccharin) and either LiCl or ethanol (2 5 g/kg, Experiment 2) Saccharin intake and emission of disgust reactions were assessed 24 and 48 hr after training Pups given paired presentations of saccharin and the aversive agents (ethanol or LiCl consumed less saccharin during the first testing clay than controls These pups also showed more aversive behavioral reactions to the gustatory CS than controls. Specifically, increased amounts of grooming, general activity, head shaking. and wall climbing as well as reduced mouthing were observed in response to the CS Conditioned aversive reactions but not taste avoidance were still evident on the second testing day In conclusion, a taste CS paired with postabsorptive effects of EtOH and LiCl elicited a similar pattern of conditioned rejection reactions in preweanling rats These results suggest that similar mechanisms may be underlying CTAs induced by LiCl and a relatively high EtOH dose (C) 2010 Wiley Periodicals, Inc Dev. Psychobiol 52 545-557, 2010
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