期刊
DEVELOPMENTAL PSYCHOBIOLOGY
卷 50, 期 3, 页码 307-313出版社
WILEY
DOI: 10.1002/dev.20287
关键词
lead; environmental enrichment; MWM; LTP; hippocampus
Lead (Pb2+) exposure in children can induce long lasting deficits in cognitive function and has been modeled in experimental animals. Based on previous studies which demonstrated that learning impairments resulting from developmental Pb2+ exposure were reversible if the animals were provided with all enriched environment, here, we asked if environmental enrichment (EE) could also reverse long-term potention (LTP) impairment induced by lead. Rats drank 1,500 ppm lead acetate (PbAc) solution or distilled water throughout gestation and lactation. After weaning at postnatal Day 22, one half of the control and lead-exposed male offspring were given the environmental enrichment treatment through all the experiments until tested. Electrophysiological and Morris water maze test were performed at 8 weeks of age. The result showed that the impaired learning ability induced by lead could be reversed by EE. Furthermore, our results revealed that EPSP LTP and PS LTP impairments induced by lead were also reversible by EE experience. (C) 2008 Wiley Periodicals, Inc.
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