期刊
DEVELOPMENTAL PSYCHOBIOLOGY
卷 50, 期 5, 页码 473-485出版社
WILEY
DOI: 10.1002/dev.20308
关键词
Fragile X; autism; arousal; emotion; attention; learning set; reversal learning; fmr1 knockout mouse; mouse; fmr1 gene; transfer of learning; Fragile X mental retardation protein (FMRP)
资金
- NICHD NIH HHS [HD04024, HD047029] Funding Source: Medline
This study was designed to further assess cognitive and affective functioning in a mouse model of Fragile X syndrome (FXS), the Fmr1(tm1Cgr) knockout (KO) mouse. Male KO mice and wild-type littermate controls were tested on learning set and reversal learning tasks. The KO mice were not impaired in associative learning, transfer of learning, or reversal learning, based on measures of learning rate. Analyses of videotapes of the reversal learning task revealed that both groups of mice exhibited higher levels of activity and wall-climbing during the initial sessions of the task than during the final sessions, a pattern also seen for trials following all error relative to those following a correct response. Notably, the increase in both behavioral measures seen early in the task was significantly more pronounced for the KO mice than for controls, as was the error-induced increase in activity level. This pattern of effects suggests that the KO mice reacted more strongly than controls to the reversal of contingencies and pronounced drop in reinforcement rate, and to errors in general. This pattern of affects is consistent with the heightened emotional reactivity frequently described for humans with FXS. (C) 2008 Wiley Periodicals, Inc.
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